Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor models.

@article{Dunlap2012DietaryEB,
  title={Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor models.},
  author={Sarah M. Dunlap and Lucia J Chiao and Leticia Nogueira and Jerry E. Usary and Charles M. Perou and Lyuba Varticovski and Stephen D. Hursting},
  journal={Cancer prevention research},
  year={2012},
  volume={5 7},
  pages={930-42}
}
Using novel murine models of claudin-low and basal-like breast cancer, we tested the hypothesis that diet-induced obesity (DIO) and calorie restriction (CR) differentially modulate progression of these aggressive breast cancer subtypes. For model development, we characterized two cell lines, "mesenchymal (M)-Wnt" and "epithelial (E)-Wnt," derived from MMTV-Wnt-1 transgenic mouse mammary tumors. M-Wnt, relative to E-Wnt, cells were tumor-initiating cell (TIC)-enriched (62% vs. 2.4% CD44(high… CONTINUE READING
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