Dietary deprivation of B-vitamins reflected in murine splenocyte proliferation in vitro.

@article{Matthews1994DietaryDO,
  title={Dietary deprivation of B-vitamins reflected in murine splenocyte proliferation in vitro.},
  author={Kathleen Shive Matthews and E Mrowczynski and R. Mark Matthews},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={198 2},
  pages={451-8}
}
The effect of murine dietary deprivation of specific B-vitamins on in vitro splenocyte proliferative response in short-term tissue culture was examined in serum-free, protein-free, minimal medium. Using different media formulations, incorporation of [3H]thymidine was used to monitor the relative growth capacity of phytohemagglutinin-stimulated splenocytes from mice exposed to different diets. The results demonstrate that the growth deficit observed in vitro in the absence of specific vitamin(s… CONTINUE READING

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