Dietary deprivation extends lifespan in Caenorhabditis elegans.

  title={Dietary deprivation extends lifespan in Caenorhabditis elegans.},
  author={Garrick D. Lee and Mark A. Wilson and Min Zhu and Catherine A. Wolkow and Rafael de Cabo and Donald K. Ingram and Sige Zou},
  journal={Aging cell},
  volume={5 6},
Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends lifespan in a variety of species; however, its underlying mechanisms remain unclear. We have found in Caenorhabditis elegans that dietary deprivation (DD) during adulthood, defined as removal of their food source Escherichia coli after the completion of larval development, increased lifespan and enhanced thermotolerance and resistance to oxidative stress. DD-induced longevity was independent of one C… CONTINUE READING
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