Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration.

@article{Coban2012DietaryCI,
  title={Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration.},
  author={Dilek Coban and Dragan Milenkovi{\'c} and Audrey Chanet and Jamila Khallou-Laschet and Linde Sabbe and Ajay Palagani and Wim Vanden Berghe and Andrzej K Mazur and Christine Morand},
  journal={Molecular nutrition & food research},
  year={2012},
  volume={56 8},
  pages={1270-81}
}
SCOPE The aim of the study was to examine the atheroprotective effect of dietary curcumin in a mouse model of atherosclerosis and to identify its cellular and molecular targets at the vascular level. METHODS AND RESULTS ApoE(-/-) mice were fed with curcumin at 0.2% (wt/wt) in diet for 4 months. This supplementation reduced the extent of atherosclerotic lesion by 26% and induced changes in expression of genes implicated in cell adhesion and transendothelial migration or cytoskeleton… CONTINUE READING
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