Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation

@inproceedings{Wang2015DietaryCI,
  title={Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation},
  author={Neng Wang and Zhiyu Wang and Yu Wang and Xiaoming Xie and Jiangang Shen and Cheng Peng and Jieshu You and Fu Chang Peng and Hailin Tang and Xinyuan Guan and Jianping Chen},
  booktitle={Oncotarget},
  year={2015}
}
Breast cancer stem cells (CSCs) are considered as the root of mammary tumorigenesis. Previous studies have demonstrated that ISL efficiently limited the activities of breast CSCs. However, the cancer prevention activities of ISL and its precise molecular mechanisms remain largely unknown. Here, we report a novel function of ISL as a natural demethylation agent targeting WIF1 to prevent breast cancer. ISL administration suppressed in vivo breast cancer initiation and progression, accompanied by… CONTINUE READING

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