Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones.

@article{Zeisel2012DietaryCD,
  title={Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones.},
  author={Steven H Zeisel},
  journal={Mutation research},
  year={2012},
  volume={733 1-2},
  pages={
          34-8
        }
}
Dietary choline is an important modulator of gene expression (via epigenetic marks) and of DNA integrity. Choline was discovered to be an essential nutrient for some humans approximately one decade ago. This requirement is diminished in young women because estrogen drives endogenous synthesis of phosphatidylcholine, from which choline can be derived. Almost half of women have a single nucleotide polymorphism that abrogates estrogen-induction of endogenous synthesis, and these women require… CONTINUE READING
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