Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

@article{Wouters2008DietaryCR,
  title={Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis},
  author={Kristiaan Wouters and Patrick J J van Gorp and Veerle Bieghs and Marion J J Gijbels and Hans J Q Duimel and Dieter L{\"u}tjohann and Anja Kerksiek and Roger van Kruchten and Nobuyo Maeda and Bart Staels and Marc van Bilsen and Ronit Shiri-Sverdlov and Marten H. Hofker},
  journal={Hepatology},
  year={2008},
  volume={48}
}
Nonalcoholic steatohepatitis (NASH) involves liver lipid accumulation (steatosis) combined with hepatic inflammation. The transition towards hepatic inflammation represents a key step in pathogenesis, because it will set the stage for further liver damage, culminating in hepatic fibrosis, cirrhosis, and liver cancer. The actual risk factors that drive hepatic inflammation during the progression to NASH remain largely unknown. The role of steatosis and dietary cholesterol in the etiology of diet… Expand
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