Dietary calcium blocks lithium toxicity in hamsters without affecting circadian rhythms.

@article{Klemfuss1992DietaryCB,
  title={Dietary calcium blocks lithium toxicity in hamsters without affecting circadian rhythms.},
  author={Harry Klemfuss and Torsten T Bauer and Kelly E. Greene and Daniel F Kripke},
  journal={Biological psychiatry},
  year={1992},
  volume={31 3},
  pages={315-21}
}
Lithium can be toxic to rodents at plasma concentrations (0.6-1.2 mmol/L) that also phase delay circadian rhythms. In hamsters, raising the concentration of calcium in the diet from 0.1%-3% reduced weight loss and polydipsia caused by 0.4% lithium carbonate. Calcium ingestion did not affect plasma lithium concentration or the phase of the circadian wheel… CONTINUE READING