Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

@article{Keaney1993DietaryAP,
  title={Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.},
  author={John F. Keaney and J. Michael Gaziano and Aiming Xu and Balz Frei and Joanne M Curran-Celentano and G T Shwaery and Joseph Loscalzo and Joseph A. Vita},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 24},
  pages={11880-4}
}
Recent evidence suggests that dietary therapy with lipid-soluble antioxidants may be beneficial for patients with atherosclerotic vascular disease but the potential mechanism(s) for these observations remain obscure. Abnormalities in endothelium-dependent control of vascular tone develop early in the course of atherosclerosis and may result from oxidative modification of low density lipoproteins. We examined the role of dietary antioxidants in preserving normal endothelial cell vasodilator… CONTINUE READING
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