Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

@article{Kim2016DietaryAL,
  title={Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine},
  author={Kwang S. Kim and Sung-Wook Hong and Daehee Han and Jaeu Yi and Jisun Jung and Bo-Gie Yang and Jun Young Lee and Minji Lee and Charles D. Surh},
  journal={Science},
  year={2016},
  volume={351},
  pages={858-863}
}
Dietary antigens are normally rendered nonimmunogenic through a poorly understood “oral tolerance” mechanism that involves immunosuppressive regulatory T (Treg) cells, especially Treg cells induced from conventional T cells in the periphery (pTreg cells). Although orally introducing nominal protein antigens is known to induce such pTreg cells, whether a typical diet induces a population of pTreg cells under normal conditions thus far has been unknown. By using germ-free mice raised and bred on… CONTINUE READING

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