Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac.

@article{Bobe2006DietaryAT,
  title={Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac.},
  author={Gerd Bobe and Bing Wang and Navindra P Seeram and Muraleedharan G Nair and Leslie D Bourquin},
  journal={Journal of agricultural and food chemistry},
  year={2006},
  volume={54 25},
  pages={9322-8}
}
A promising approach for cancer chemoprevention might be a combination therapy utilizing dietary phytochemicals and anticarcinogenic pharmaceuticals at a suboptimal dosage to minimize any potential adverse side effects. To test this hypothesis, various dosages of anthocyanin-rich tart cherry extract were fed in combination with suboptimal levels of the nonsteroidal anti-inflammatory drug sulindac to APCMin mice for 19 weeks. By the end of the feeding period, fewer mice that were fed the… CONTINUE READING

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