Dietary and Metabolic Manipulations of the Carcinogenic Process: Role of Nucleotide Pool Imbalances in Carcinogenesis

@article{Rao1987DietaryAM,
  title={Dietary and Metabolic Manipulations of the Carcinogenic Process: Role of Nucleotide Pool Imbalances in Carcinogenesis},
  author={P. Rao and E. Laconi and S. Vasudevan and A. Denda and S. Rajagopal and S. Rajalakshmi and D. Sarma},
  journal={Toxicologic Pathology},
  year={1987},
  volume={15},
  pages={190 - 193}
}
Perturbations in DNA and/or membranes are considered to be important for the carcinogenic process. A search for nutritional and metabolic means of disturbing the homeostasis of DNA and membranes revealed that nucleotide pools of fer an exciting possibility. An imbalance in nucleotide pools can exert a two-pronged attack on both DNA and membranes. When given to rats, orotic acid, a precursor of pyrimidine nucleotides, results in an imbalance in nucleotide pools (an increase in uridine… Expand
Metabolic effect of orotic acid in calves.
Modulation by Vitamins
Descriptive animal toxicology tests

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