Dietary acrylamide and cancer risk: An updated meta‐analysis

@article{Pelucchi2015DietaryAA,
  title={Dietary acrylamide and cancer risk: An updated meta‐analysis},
  author={Claudio Pelucchi and Cristina Bosetti and Carlotta Galeone and Carlo la Vecchia},
  journal={International Journal of Cancer},
  year={2015},
  volume={136}
}
The debate on the potential carcinogenic effect of dietary acrylamide is open. In consideration of the recent findings from large prospective investigations, we conducted an updated meta‐analysis on acrylamide intake and the risk of cancer at several sites. Up to July 2014, we identified 32 publications. We performed meta‐analyses to calculate the summary relative risk (RR) of each cancer site for the highest versus lowest level of intake and for an increment of 10 µg/day of dietary acrylamide… Expand
No association between dietary acrylamide and renal cell carcinoma: An updated meta-analysis.
TLDR
Dietary acrylamide is not related to the risk of renal cell carcinoma, according to a meta-analysis of 8 studies, 2843 cases and 309 controls/participants. Expand
No association between dietary acrylamide and renal cell carcinoma: an updated meta-analysis.
TLDR
Dietary acrylamide is not related to the risk of renal cell carcinoma, according to a meta-analysis of eight epidemiological studies and 309 920 controls/participants. Expand
The association between high oral intake of acrylamide and risk of breast cancer: An updated systematic review and meta-analysis
TLDR
The correlation between high oral intake of acrylamide and breast cancer risk was assessed with the aid of meta-analysis and the pooled relative risk (RRs) of breast cancer was significance. Expand
Dietary Acrylamide Intake and Risk of Renal Cell Carcinoma in Two Large Prospective Cohorts
TLDR
Dietary acrylamide intake was not associated with risk of RCC in two long-term prospective cohorts with repeated measures of dietary intake, adding to the body of evidence that dietary acylamide is not an important cancer risk factor in humans. Expand
Dietary Acrylamide Intake and the Risk of Pancreatic Cancer: The Japan Public Health Center-Based Prospective Study
TLDR
Dietary acrylamide intake was not associated with the pancreatic cancer risk in Japanese individuals and in the analyses stratified by sex, smoking status, coffee consumption, green tea consumption, alcohol consumption, and body mass index, no significant association was detected. Expand
Dietary acrylamide intake and risk of women’s cancers: a systematic review and meta-analysis of prospective cohort studies
TLDR
No significant association was found between dietary acrylamide intake and the risk of breast, endometrial and ovarian cancers in different subgroup analyses by smoking status, menopausal status, BMI status and different types of breast cancer. Expand
A prospective cohort study on dietary acrylamide intake and the risk for cutaneous malignant melanoma
TLDR
This study provides some indications that dietary acrylamide may increase the risk for CMM in men and a case–cohort analysis within the prospective Netherlands Cohort Study on diet and cancer. Expand
Dietary acrylamide intake and the risk of endometrial or ovarian cancers in Japanese women
TLDR
Dietary acylamide intake was not associated with the risk of endometrial or ovarian cancer in Japanese women with a relatively lower dietary intake of acrylamide compared with Western populations. Expand
Dietary acrylamide and the risk of pancreatic cancer in the International Pancreatic Cancer Case–Control Consortium (PanC4)
TLDR
This PanC4 pooled-analysis found no association between dietary acrylamide from diet and pancreatic cancer risk. Expand
Dietary Acrylamide Intake and Risk of Esophageal, Gastric, and Colorectal Cancer: The Japan Public Health Center–Based Prospective Study
TLDR
Dietary acrylamide intake was not associated with increased risk of esophageal, gastric, or colorectal cancer among the Japanese population and no significant associations were observed when the participants were stratified by cancer subsites. Expand
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BACKGROUND Acrylamide has been associated to cancer risk in rodents, but data on humans are inconclusive. We thus carried out a critical review and meta-analysis of studies of exposure to acrylamideExpand
Dietary acrylamide and risk of renal cell cancer
TLDR
There is no association between dietary acrylamide intake through diet and risk of renal cell cancer, and data from a large population‐based Swedish case‐control study of kidney cell cancer is reanalyzed. Expand
A Prospective Study of Dietary Acrylamide Intake and the Risk of Endometrial, Ovarian, and Breast Cancer
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The Netherlands Cohort Study on diet and cancer observed increased risks of postmenopausal endometrial and ovarian cancer with increasing dietary acrylamide intake, particularly among never-smokers. Expand
Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer.
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There were some indications for a positive association between dietary acrylamide and renal cell cancer risk and there were no positive associations with bladder and prostate cancer risk. Expand
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TLDR
No evidence is provided that dietary acrylamide in amounts typically consumed by Swedish men is associated with risk of colorectal cancer, and the multivariate rate ratios for the highest quartile were higher than expected. Expand
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Overall, acrylamide intake was not associated with colorectal, gastric, pancreatic, and esophageal cancer risk, but some subgroups deserve further attention. Expand
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TLDR
The authors state: ‘The first study of dietary acrylamide in relation to three major human cancers is reassuring’, but it is not realistic that not even a ‘true’ relative risk as high as 2.4 could have been detected in the Swedish study. Expand
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TLDR
No evidence that dietary intake of acrylamide is associated with cancers of the colon or rectum is found in this large prospective study using prospective data from the Swedish Mammography Cohort. Expand
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TLDR
The collective evidence suggests that a high level of dietary acrylamide intake is not a risk factor for breast, endometrial, or ovarian cancers, which have generated particular interest because of a conjectured hormonal mechanism of acylamide. Expand
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TLDR
In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile; however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acryamide is not an important risk factor for EC. Expand
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