Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans

@inproceedings{Heestand2013DietaryRI,
  title={Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans},
  author={Bree N. Heestand and Yidong Shen and Wei Liu and Daniel B. Magner and Nadia Storm and Caroline Meharg and Bianca H Habermann and Adam Antebi},
  booktitle={PLoS genetics},
  year={2013}
}
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels… CONTINUE READING