Dietary Polyphenols and the Prevention of Diseases

@article{Scalbert2005DietaryPA,
  title={Dietary Polyphenols and the Prevention of Diseases},
  author={Augustin Scalbert and Claudine Manach and Christine Morand and Christian Rémésy and Liliana Valdez Jim{\'e}nez},
  journal={Critical Reviews in Food Science and Nutrition},
  year={2005},
  volume={45},
  pages={287 - 306}
}
Polyphenols are the most abundant antioxidants in the diet and are widespread constituents of fruits, vegetables, cereals, dry legumes, chocolate, and beverages, such as tea, coffee, or wine. Experimental studies on animals or cultured human cell lines support a role of polyphenols in the prevention of cardiovascular diseases, cancers, neurodegenerative diseases, diabetes, or osteoporosis. However, it is very difficult to predict from these results the effects of polyphenol intake on disease… 
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Protective Effects of Dietary Polyphenols in Human Diseases and Mechanisms of Action

Modulation of multiple cell signaling pathways, including transcription factor NF-E2-related factor 2, nuclear factor-κB, mitogen-activated protein kinases, cytokines, cyclooxygenase, lipoxygenases, apoptosis-related proteins, and cell cycle proteins could explain the antioxidant actions of dietary polyphenols.

Polyphenols and prevention of cardiovascular diseases

Future intervention studies should include a detailed assessment of the bioavailability of polyphenols, and more studies with purepolyphenols will also be needed to establish their role in the prevention of cardiovascular diseases.

Cocoa, Flavonoids and Cardiovascular Protection

Polyphenols as dietary supplements: A double-edged sword

A considerable amount of evidence is accumulating which supports the hypothesis that high-dose polyphenols can mechanistically cause adverse effects through pro-oxidative action, and polyphenol-rich dietary supplements can potentially confer additional benefits but high-doses may elicit toxicity thereby establishing a double-edge sword in supplement use.

Natural Polyphenols: Potential for Disease Prevention

It is absolutely vital to realize that the intake of polyphenols-rich foods has to be considered as protective measure against the development of the epidemic of chronic diseases rather than a cure, at least for the present time.

Chapter 100 – Polyphenols and Breast Cancer Prevention: A Summary of the Epidemiologic Evidence

Polyphenols and Skin Cancers

Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion

Dietary Anti-Aging Polyphenols and Potential Mechanisms

The aim of this review is to critically evaluate the experimental evidence demonstrating the beneficial effects of polyphenols on aging-related diseases, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, and promoting mitochondrial function.

Potential role of phytochemicals in metabolic syndrome prevention and therapy

Clinical studies are needed to better understand the role of bioactive compounds in the prevention and management of MetS, as inconsistent or conflicting results have been found in clinical trials when other promising compounds in vitro or in animal studies were used.
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