Dietary Omega-3 Polyunsaturated Fatty Acid Supplementation and Airway Hyperresponsiveness in Asthma

@article{Mickleborough2005DietaryOP,
  title={Dietary Omega-3 Polyunsaturated Fatty Acid Supplementation and Airway Hyperresponsiveness in Asthma},
  author={Timothy D. Mickleborough},
  journal={Journal of Asthma},
  year={2005},
  volume={42},
  pages={305 - 314}
}
Asthma prevalence continues to increase despite the progress that has been made in the treatment options for asthma. Alternative treatment therapies that reduce the dose requirements of pharmacological interventions would be beneficial, and could potentially reduce the public health burden of this disease. There is accumulating evidence that dietary modification has potential to influence the severity of asthma and reduce the prevalence and incidence of this condition. A possible contributing… 
The potential effects of omega-3 fatty acids on asthma pathogenesis.
TLDR
Interventions including dietary changes before the sensitization and remodelling period would be beneficial in terms of preventing changes in asthma and potential targets for omega-3 fatty acids are discussed.
Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications
TLDR
Mechanistically, most evidence suggests that omega-3 fatty acids reduce the synthesis and secretion of very-low-density lipoprotein (VLDL) particles, and increase TG removal from VLDL and chylomicron particles through the upregulation of enzymes, such aslipoprotein lipase.
Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation
TLDR
Data presented demonstrated that the n-6 FA-rich diet had protective effect upon allergic airway inflammation and was as anti-inflammatory as the n -3 FA- rich diet, although through different mechanisms, suggesting that both diets could be considered as complementary therapy or a prophylactic alternative for allergic airways inflammation.
Dietary Enrichment with 20% Fish Oil Decreases Mucus Production and the Inflammatory Response in Mice with Ovalbumin-Induced Allergic Lung Inflammation
TLDR
Enrichment with dietary (n-3) PUFA decreased mucus production in lung tissues of OVA-sensitized and challenged mice and reversed the increase in PAS+ mucus-producing cells.
Lipid mediator profiling in pulmonary disease.
TLDR
The state-of-the-art methodology in profiling of oxylipins via mass spectrometry is summarized including sample work-up and data processing, and new data will increase the insight into disease processes and have great potential to identify new biomarkers for disease diagnosis as well as novel therapeutic targets.
HOLISTIC SUPPLEMENT OMEGA FATTY ACIDS: A CHALLENGE FOR SMART HEART BY SAYING NO TO ATHEROSCELEROSIS AND YES TO HOMEOSTASIS
TLDR
Omega-3/5/6/7/9 fatty acids are considered as essential fatty acids and appear to be important for cognitive (brain memory and performance) and behavioral function, as well as normal growth and development.
Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation
TLDR
Isomers of protectin D1 were synthesized using soybean lipoxygenase and tested for their ability to inhibit human blood platelet aggregation, concluding that PDX and other oxygenated products from PUFAs of nutritional interest, having the E,Z,E‐conjugated triene motif and collectively named poxytrins (PUFA oxygenated trienes), might have antithrombotic potential.
PHARMACEUTICAL TASTE MASKING TECHNOLOGIES OF BITTER DRUGS: A CONCISE REVIEW
TLDR
This review shall look into different PLA2 enzymes and their role in generation of bioactive mediators and why in spite of controlling generation of all eicosanoids, PLA2 inhibitors did not show efficacy in clinical trials with special reference to respiratory diseases.
Genetic and Environmental Factors in Asthma
TLDR
Many environmental factors which influence asthma development and exacerbation, genetic factors which have been identified as risk factors for developing asthma, and examples of gene-by-environment interactions in expression of this disease are examined.
Air pollution, oxidative stress and dietary supplementation: a review
TLDR
There is substantial evidence that air pollution exposure results in increased oxidative stress and that dietary supplementation may play a modulating role on the acute effect of air pollutants.
...
1
2
3
...

References

SHOWING 1-10 OF 126 REFERENCES
Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma.
TLDR
Dietary supplementation with fish oil rich in the omega-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic Acid is beneficial for children with bronchial asthma in a strictly controlled environment in terms of inhalant allergens and diet.
Effect of Dietary Supplementation with Polyunsaturated Fatty Acids on Bronchial Hyperreactivity in Subjects with Seasonal Asthma
TLDR
The present data strongly suggest the hypothesis that dietary supplementation with omega-3 essential fatty acids could decrease bronchial hyperreactivity in atopic patients.
Effect of dietary supplementation with fish oil lipids on mild asthma.
TLDR
It is concluded that in subjects with mild asthma a fish oil enriched diet attenuates neutrophil function without changing the severity of asthma.
Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production.
TLDR
The effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population was determined and alterations in urinary 5-series leukotriene excretion predicted treatment efficacy.
Dietary Components with Demonstrated Effectiveness in Decreasing the Severity of Exercise-Induced Asthma
TLDR
Since EIA is part of the asthmatic diathesis, it is possible that EIA may serve as a useful model for investigation of potential dietary interventions for reducing airway hyperresponsiveness.
Dietary fat and asthma: is there a connection?
TLDR
Changes in the diet may explain the increase in the prevalence of asthma, eczema and allergic rhinitis, and the effects of diet may be mediated through an increased in the synthesis of prostaglandin E2 which in turn can promote the formation of immunoglobulin E.
Modulation of human immune and inflammatory responses by dietary fatty acids.
Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma.
TLDR
It is suggested that perilla seed oil-rich supplementation is useful for the treatment of asthma in terms of suppression of LTB4 and LTC4 generation by leucocytes, and improvement of pulmonary function.
Effect of eicosapentaenoic acid in asthma
TLDR
The substitution of EPA for arachidonic acid metabolites in patients might cause a decrease in airway inflammation and an improvement in clinical asthma.
...
1
2
3
4
5
...