Dietary Non-Esterified Oleic Acid Decreases the Jejunal Levels of Anorectic N-Acylethanolamines

  title={Dietary Non-Esterified Oleic Acid Decreases the Jejunal Levels of Anorectic N-Acylethanolamines},
  author={Thi Ai Diep and Andreas Nygaard Madsen and Sandra Krogh-Hansen and Marwa Al-Shahwani and Laila Al-Sabagh and Birgitte Holst and Harald S Hansen},
  journal={PLoS ONE},
Background and Aims Oleoylethanolamide and several other N-acylethanolamines (NAEs), e.g. linoleoylethanolamide and palmitoylethanolamide, have anorectic properties in rats, and prolonged intake of a high-fat diet decreases the levels of the anorectic NAEs in jejunum. Jejunal anorectic NAEs are thought to add to the control of food intake via activation of PPARalpha and the vagus nerve. The fat-induced decrease may explain part of the hyperphagic effect of high-fat diets. In the present study… 

Figures and Tables from this paper

Oleoylethanolamide: The role of a bioactive lipid amide in modulating eating behaviour
  • J. Sihag, P. J. Jones
  • Biology
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2018
Evidence indicates that intake of oleic acid, and thereby the resulting OEA imparting anorexic properties, is dependent on CD36, PPAR‐α, enterocyte fat sensory receptors, histamine, oxytocin and dopamine; leading to increased fat oxidation and enhanced energy expenditure to induce satiety and increase feeding latency; and that a disruption in any of these systems will cease/curb fat‐induced satiety.
Non‐endocannabinoid N‐acylethanolamines and 2‐monoacylglycerols in the intestine
The putative biosynthetic pathways and targets of NAEs in the intestine as well as their anorectic role and changes in intestinal levels depending on the dietary status are discussed.
Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor−/− Mice Improves Indices of Cardiometabolic Disease
The results suggest that incorporation of NAPE expressing bacteria into the gut microbiota can potentially serve as an adjuvant therapy to retard development of cardiometabolic disease.
Dietary fatty acid composition impacts plasma fatty acid ethanolamide levels and body composition in golden Syrian hamsters.
It is concluded that the addition of HOCO to diets aids in the reduction of food intake, which may contribute to the maintenance of healthy body weight.
Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor.
It is shown that 2-OG stimulates GLP-1 secretion through GPR119 activation in vitro, and that fat-derived 2-MAGs are potent candidates for mediating fat-induced GLP -1 release through G PR119 in vivo.
The effects of oleoylethanolamide, an endogenous PPAR‐α agonist, on risk factors for NAFLD: A systematic review
The evidence reviewed in this article illustrates that OEA regulates multiple biological processes associated with NAFLD, including lipid metabolism, inflammation, oxidative stress, and energy homeostasis through different mechanisms.


Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor
  • T. Diep, A. Madsen, H. Hansen
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2011
The intestinal NAE levels are reduced in a dose‐ and time‐dependent manner in response to dietary fat intake, and this may contribute to the well‐known hyperphagic effect of HFDs.
Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat.
Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors.
Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice
The results might suggest that elevation of gastric OEA could possibly contribute to the delayed gastric emptying observed in HFD-fed animals, and underlie part of the anorexic effects of this compound.
Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice.
N-acylethanolamines, anandamide and food intake.
Modulation of Meal Pattern in the Rat by the Anorexic Lipid Mediator Oleoylethanolamide
The results suggest that OEA may participate in the regulation of satiety and may provide a chemical scaffold for the design of novel appetite-suppressing medications.
Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats.
Pharmacological administration of the natural lipid amide, oleoylethanolamide (OEA), inhibits food intake in free-feeding rodents by prolonging latency to feed and postmeal interval. This anorexic
Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine.