Dietary Non-Esterified Oleic Acid Decreases the Jejunal Levels of Anorectic N-Acylethanolamines

@article{Diep2014DietaryNO,
  title={Dietary Non-Esterified Oleic Acid Decreases the Jejunal Levels of Anorectic N-Acylethanolamines},
  author={Thi Ai Diep and Andreas Nygaard Madsen and Sandra Krogh-Hansen and Marwa Al-Shahwani and Laila Al-Sabagh and Birgitte Holst and Harald S Hansen},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Background and Aims Oleoylethanolamide and several other N-acylethanolamines (NAEs), e.g. linoleoylethanolamide and palmitoylethanolamide, have anorectic properties in rats, and prolonged intake of a high-fat diet decreases the levels of the anorectic NAEs in jejunum. Jejunal anorectic NAEs are thought to add to the control of food intake via activation of PPARalpha and the vagus nerve. The fat-induced decrease may explain part of the hyperphagic effect of high-fat diets. In the present study… 

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