Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat

@article{Relton1993DietaryNF,
  title={Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat},
  author={Jane K. Relton and Paul J Strijbos and A. L. Cooper and Nancy J. Rothwell},
  journal={Brain Research Bulletin},
  year={1993},
  volume={32},
  pages={223-226}
}
Arachidonic acid [20:4(N-6)] has been implicated in neurological damage induced by cerebral ischaemia. Membrane arachidonate concentrations can be reduced by changes in dietary fat intake. Therefore, in the present study, we have investigated the effects of N-3 fatty acid supplementation on neuronal damage induced by permanent focal cerebral ischaemia or pharmacological activation of striatal NMDA receptors. Weanling rats were fed either a control diet or an N-3 supplemented diet (1.75% by… CONTINUE READING

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