Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine.

@article{Owen2001DietaryLS,
  title={Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine.},
  author={Kevin Q Owen and Harjeet Jit and Charles V. Maxwell and Jim L. Nelssen and Robert D. Goodband and Mike D. Tokach and George C. Tremblay and Sung I. Koo},
  journal={Journal of animal science},
  year={2001},
  volume={79 12},
  pages={3104-12}
}
A trial was conducted to biochemically explain the decreased lipid deposition and increased protein accretion observed in pigs fed carnitine. Our hypothesis was that an increase in the ratio of acetyl CoA:CoA-SH produced by stimulation of fatty acid oxidation by supplemental L-carnitine may decrease branched-chain alpha-keto acid dehydrogenase activity and increase pyruvate carboxylase activity. Such changes could reduce oxidative loss of branched-chain amino acids and provide more carbons for… CONTINUE READING

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