Dietary Intervention to Reverse Carotid Atherosclerosis

@article{Shai2010DietaryIT,
  title={Dietary Intervention to Reverse Carotid Atherosclerosis},
  author={Iris Shai and John David Spence and Dan Schwarzfuchs and Yaakov Henkin and Grace Parraga and Assaf Rudich and Aaron Fenster and Christiane L. Mallett and Noah Liel-Cohen and Amir Tirosh and Arkady Bolotin and Joachim Thiery and Georg Martin Fiedler and Matthias Bl{\"u}her and Michael Stumvoll and Meir J. Stampfer},
  journal={Circulation},
  year={2010},
  volume={121},
  pages={1200-1208}
}
Background— It is currently unknown whether dietary weight loss interventions can induce regression of carotid atherosclerosis. Methods and Results— In a 2-year Dietary Intervention Randomized Controlled Trial–Carotid (DIRECT-Carotid) study, participants were randomized to low-fat, Mediterranean, or low-carbohydrate diets and were followed for changes in carotid artery intima-media thickness, measured with standard B-mode ultrasound, and carotid vessel wall volume (VWV), measured with carotid… Expand

Paper Mentions

Interventional Clinical Trial
Aim-to conduct a randomized clinical intervention study to compare three diets (low-fat, low-carbohydrate and Mediterranean diet) for weight loss  
ConditionsCHD, Obesity
InterventionBehavioral
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Two-year decreases in systolic blood pressure were independently associated with regression in carotid-VWV, and those with the higher baseline plaque burden, whom were assigned to drink wine, reduced their plaque volume significantly after 2 years, as compared to baseline. Expand
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Also in obese children with NAFLD arterial function may be restored by improving metabolic risk factors and reducing visceral adiposity following a 1-year lifestyle intervention. Expand
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Among postmenopausal women, a dietary intervention aimed at reducing total fat intake and encouraging increased intake of fruit, vegetables, and grains did not significantly change the risk for incident carotid artery disease. Expand
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TLDR
This study suggests that, independent of measures of adiposity, a Mediterranean dietary pattern is associated with lower insulin resistance. Expand
arotid intima-media thickness changes with Mediterranean diet : A randomized rial ( PREDIMED-Navarra )
Objective: Observational studies have reported inverse associations between adherence to the Mediterranean diet (MedDiet) and atherosclerotic disease. We tested the effect of two types of MedDiet onExpand
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TLDR
Of the traditional CVD risk factors, only systolic BP, fasting glucose, body composition, and total cholesterol/HDL ratio have a direct relationship with mean carotid IMT. Expand
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TLDR
Moderate and strict adherence to a MeDi may protect against a higher burden of carotid atherosclerotic plaque, which may mediate the protection against clinical vascular events. Expand
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TLDR
A remarkable C-IMT regression occurred as early as 1–2 months after BS in obese patients either with or without type 2 diabetes, which was associated to the early reduction in leptin, (at least partially) independent of weight loss. Expand
Changes in Ultrasound-Assessed Carotid Intima-Media Thickness and Plaque With a Mediterranean Diet: A Substudy of the PREDIMED Trial
TLDR
Compared with a control diet, consumption of a MedDiet supplemented with nuts is associated with delayed progression of ICA-IMT and plaque, which contribute mechanistic evidence for the reduction of cardiovascular events observed in the PREDIMED trial. Expand
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