• Corpus ID: 28129268

Dietary Ingredient for Prevention of Metabolic Syndrome , Antioxidation and Cosmetics

  title={Dietary Ingredient for Prevention of Metabolic Syndrome , Antioxidation and Cosmetics},
  • Published 2009
1 Citations
Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology
This study found that fucoxanthin yield from F. vesiculosus may be maximised by incubating at 30.0 °C for 36.5 min, pH 5.7, with 62.2 % acetone, while holdfasts contained the least.


Cancer chemoprevention by natural carotenoids and their related compounds
  • H. Nishino
  • Biology, Medicine
    Journal of cellular biochemistry. Supplement
  • 1995
Fucoxanthin, a carotenoid as abundant in nature as β‐carotene, was also found to have antitumorigenic activity in mouse skin and duodenum models and should be carried out in the field of cancer chemoprevention.
Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D.
The results of this study suggest that fucoxanthin may be useful in chemoprevention of other human malignancies and may be related to the antitumorgenic activity.
Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient.
Fucoxanthin has a unique structure including an unusual allenic bond and 5, 6-monoepoxide in its molecule. We found that abdominal white adipose tissue (WAT) weights of rats and mice fed fucoxanthin
Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice.
The results suggest that dietary fucoxanthin decreases the blood glucose and plasma insulin concentration of KK- A(y) along with down-regulating TNFalpha mRNA, and the combination of fu Coxanthin and fish oil is more effective for attenuating the weight gain of WAT than feeding with fucox anthin alone.
Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin.
Un Uncoupling protein 1 (UCP1), a key molecule for metabolic thermogenesis, was clearly expressed in the white adipose tissue (WAT) of mice fed Fc, but little expression in that of the mice fed MCT.
Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice.
Results indicate for the first time that dietary fu Coxanthin and fucoxanthinol enhance the amount of DHA in the liver of KKAy mice, a model for obese/type II diabetes.
Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells.
GADD45A may be involved in fucoxanthin-induced G1 arrest, a cell cycle-related gene, in HepG2 and DU145 cells, and the introduction of siRNA against Gadd45A partially perturbed the induction of Gi arrest by fu Coxanthin in both cell types.
Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites.
Hydroxyl radical scavenging activity of fucoxanthin and fu Coxanthinol compared with halocynthiaxanthin is assumed to be due to presence of the allenic bond, and ESR analysis of the superoxide radical scavenge activity showed the superiority of fuoxanthin over the other two carotenoids tested.
Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.
Results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases.
Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells.
The results suggest that fucoxanthin and fu Coxanthinol inhibit the adipocyte differentiation of 3T3-L1 cells through down-regulation of PPARgamma.