Dietary Flavonoids and Acarbose Synergistically Inhibit α-Glucosidase and Lower Postprandial Blood Glucose.

@article{Zhang2017DietaryFA,
  title={Dietary Flavonoids and Acarbose Synergistically Inhibit $\alpha$-Glucosidase and Lower Postprandial Blood Glucose.},
  author={Bowei Zhang and Xia Li and Wenlong Sun and Y-Q Xing and Zhilong Xiu and Chunlin Zhuang and Yuesheng Dong},
  journal={Journal of agricultural and food chemistry},
  year={2017},
  volume={65 38},
  pages={
          8319-8330
        }
}
The inhibition of porcine pancreatic α-amylase and mammalian α-glucosidase by 16 individual flavonoids was determined. The IC50 values for baicalein, (+)-catechin, quercetin, and luteolin were 74.1 ± 5.6, 175.1 ± 9.1, 281.2 ± 19.2, and 339.4 ± 16.3 μM, respectively, against α-glucosidase. The IC50 values for apigenin and baicalein were 146.8 ± 7.1 and 446.4 ± 23.9 μM, respectively, against α-amylase. The combination of baicalein, quercetin, or luteolin with acarbose showed synergistic… 
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