Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells.

@article{Tsai2016DietaryFL,
  title={Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells.},
  author={Pei-Hsun Tsai and Chia-Hsiung Cheng and Chun-Yu Lin and Y T Huang and Lung-Ta Lee and Chithan C. Kandaswami and Yo-Chuen Lin and Kevin Po-Hao Lee and Chin-Chun Hung and J J Hwang and F. J. Ke and G Y Chang and M Lee},
  journal={Anticancer research},
  year={2016},
  volume={36 12},
  pages={6367-6380}
}
A highly invasive Du145-III subline was isolated by three successive passages of the parental Du145 prostate tumor cell line (Du145-P) through a Boyden chamber with matrigel-coated membrane support. Du145-III cells showed great invasion potential based on their increased ability to spread/migrate and enhanced expression/secretion of the matrix metalloproteinase 9 (MMP9). Du145-III cells exerted vasculogenic mimicry (VM) properties, reminiscent of endothelial cell characteristics and expressed… CONTINUE READING
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