Dietary Activators of Sirt 1

@inproceedings{Allard2009DietaryAO,
  title={Dietary Activators of Sirt 1},
  author={Joanne S. Allard and Evelyn V Perez and Sige Zou and Rafael C. de Cabo},
  year={2009}
}
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the Sir2 histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary… CONTINUE READING
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