Dietary Acid-Base Balance, Bone Resorption, and Calcium Excretion

@article{Jajoo2006DietaryAB,
  title={Dietary Acid-Base Balance, Bone Resorption, and Calcium Excretion},
  author={Ramina Jajoo and Lingyi Song and Helen M. Rasmussen and Susan S. Harris and Bess Dawson-Hughes},
  journal={Journal of the American College of Nutrition},
  year={2006},
  volume={25},
  pages={224 - 230}
}
Objective: Metabolic studies reveal that acidogenic diets increase bone resorption acutely. This study was conducted to examine associations between diet-induced changes in net acid excretion (NAE) and changes in serum parathyroid hormone (PTH), bone resorption, and calcium excretion over a longer period of 60 days. Methods: Forty healthy older men and women were given 0.75 g/kg of protein as meat, 600 mg of calcium, and 400 IU of vitamin D3 daily and either cereal (acidogenic) or fruit and… 
POTASSIUM CITRATE DECREASES BONE RESORPTION IN POSTMENOPAUSAL WOMEN WITH OSTEOPENIA: A RANDOMIZED, DOUBLE-BLIND CLINICAL TRIAL.
  • N. S. Gregory, Rekha Kumar, J. S. Rodman
  • Medicine, Biology
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2015
TLDR
In women with postmenopausal osteopenia, treatment with K- citrate for 1 year resulted in a significant decrease in markers of turnover, and K-citrate may serve as a potential treatment for bone loss that is well tolerated and without any significant known long-term consequences.
Dietary acid load in early life and bone health in childhood: the Generation R Study.
TLDR
Dietary acid load in early life was not consistently associated with bone health in childhood, and further research is needed to explore the extent to which dietary Acid load in later childhood may affect current and future bone health.
Dietary protein and bone health: harmonizing conflicting theories.
TLDR
When positive and negative pathways are considered in tandem, protein may offer modest benefits to bone in the presence of adequate dietary calcium and acid-neutralizing fruits and vegetables.
A positive association of dietary protein with lumbar spine bone mineral density is suppressed by a negative association of protein sulfur
TLDR
Results suggest that protein intake is positively associated with aBMD, but benefit at the LS is offset by a negative impact of the protein sulfur acid load, harmonize conflicting theories on the role of dietary protein in bone health.
A positive association of lumbar spine bone mineral density with dietary protein is suppressed by a negative association with protein sulfur.
TLDR
Results suggest that protein intake is positively associated with aBMD, but benefit at the LS is offset by a negative impact of the protein sulfur acid load, which harmonize conflicting theories on the role of dietary protein in bone health.
Pathways for theoretical positive and negative influences of dietary protein on bone health
TLDR
When positive and negative pathways are considered in tandem, protein may offer modest benefits to bone in the presence of adequate dietary calcium and acid-neutralizing fruits and vegetables.
Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis.
TLDR
Evidence suggests a linear association between changes in calcium excretion in response to experimental changes in net acid excretion, however, this finding is not evidence that the source of the excreted calcium is bone or that this calciuria contributes to the development of osteoporosis.
Effects of dietary electrolyte balance and calcium supply on mineral and acid−base status of piglets fed a diversified diet
TLDR
A higher Ca supply must be considered in more diversified diets to counteract the risk of evolving towards low-grade metabolic acidosis which can negatively affect bone.
Metabolic advantages of higher protein diets and benefits of dairy foods on weight management, glycemic regulation, and bone.
  • S. Pasiakos
  • Biology, Medicine
    Journal of food science
  • 2015
TLDR
The scientific literature assessing metabolic advantages associated with higher protein diets on weight management, glycemic regulation, and bone is reviewed, with emphasis given to studies evaluating the potential benefits associated with dairy.
Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality
TLDR
A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health.
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