Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation.

@article{Holy2011DietaryA,
  title={Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation.},
  author={Erik Walter Holy and Marc Forestier and Eva Katharina Richter and Alexander Akhmedov and Florian Leiber and Giovanni G Camici and Pavani S Mocharla and Thomas Felix L{\"u}scher and Juerg Hans Beer and Felix C. Tanner},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 8},
  pages={1772-80}
}
OBJECTIVE Plant-derived α-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n-3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown. METHODS AND RESULTS Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial thrombus formation was delayed in mice fed a high-ALA diet compared with those on a low-ALA diet (n=7; P<0.005). Dietary ALA impaired platelet aggregation to collagen and thrombin… CONTINUE READING
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