Diet-induced type II diabetes in C57BL/6J mice.

  title={Diet-induced type II diabetes in C57BL/6J mice.},
  author={Richard S. Surwit and Cynthia M. Kuhn and C L Cochrane and James A. McCubbin and Mark Feinglos},
  volume={37 9},
We investigated the effects of diet-induced obesity on glucose metabolism in two strains of mice, C57BL/6J and A/J. Twenty animals from each strain received ad libitum exposure to a high-fat high-simple-carbohydrate diet or standard Purina Rodent Chow for 6 mo. Exposure to the high-fat, high-simple-carbohydrate, low-fiber diet produced obesity in both A/J and C57BL/6J mice. Whereas obesity was associated with only moderate glucose intolerance and insulin resistance in A/J mice, obese C57BL/6J… CONTINUE READING
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