Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer.

@article{Liu2012DietinducedOE,
  title={Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer.},
  author={Zhenhua Liu and Ryan S Brooks and Eric D Ciappio and Susan Kim and Jimmy W. Crott and Grace L Bennett and Andrew S Greenberg and Joel B. Mason},
  journal={The Journal of nutritional biochemistry},
  year={2012},
  volume={23 10},
  pages={1207-13}
}
Inflammation associated with obesity may play a role in colorectal carcinogenesis, but the underlying mechanism remains unclear. This study investigated whether the Wnt pathway, an intracellular signaling cascade that plays a critical role in colorectal carcinogenesis, is activated by obesity-induced elevation of the inflammatory cytokine tumor necrosis factor-alpha (TNF-α). Animal studies were conducted on C57BL/6 mice, and obesity was induced by utilizing a high-fat diet (60% kcal). An… CONTINUE READING

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