Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice

@inproceedings{Griffin2010DietinducedOD,
  title={Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice},
  author={Timothy M Griffin and Beverley Fermor and J L A - NIH Huebner and Virginia B. Kraus and Ramona Marie Rodriguiz and William C. Wetsel and Li Cao and Lori A. Setton and Farshid Guilak},
  booktitle={Arthritis research & therapy},
  year={2010}
}
INTRODUCTION Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet. METHODS Female C57BL/6J… CONTINUE READING
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