Diet-induced obesity attenuates endotoxin-induced cognitive deficits.

  title={Diet-induced obesity attenuates endotoxin-induced cognitive deficits.},
  author={Sharay E. Setti and Alyssa M. Littlefield and Samantha W Johnson and Rachel A. Kohman},
  journal={Physiology & behavior},
Activation of the immune system can impair cognitive function, particularly on hippocampus dependent tasks. Several factors such as normal aging and prenatal experiences can modify the severity of these cognitive deficits. One additional factor that may modulate the behavioral response to immune activation is obesity. Prior work has shown that obesity alters the activity of the immune system. Whether diet-induced obesity (DIO) influences the cognitive deficits associated with inflammation is… CONTINUE READING