Diet-induced obese mice are leptin insufficient after weight reduction.

  title={Diet-induced obese mice are leptin insufficient after weight reduction.},
  author={Haifei Shi and Shailaja Akunuru and John C Bierman and Karen M B Hodge and M Chrissy Mitchell and M T Foster and Randy J Seeley and Ofer Reizes},
  volume={17 9},
Behavioral therapies aimed at reducing excess body fat result in limited fat loss after dieting. To understand the causes for maintenance of adiposity, high-fat (HF) diet-induced obese (DIO) mice were switched to a low-fat chow diet, and the effects of chow on histological and molecular alterations of adipose tissue and metabolic parameters were examined. DIO mice reduced and stabilized their body weights after being switched to chow (HF-chow), but retained a greater amount of adiposity than… CONTINUE READING


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