Diet-induced metabolic change induces estrogen-independent allometric mammary growth.

Abstract

Lifetime breast cancer risk reflects an unresolved combination of early life factors including diet, body mass index, metabolic syndrome, obesity, and age at first menses. In parallel, the onset of allometric growth by the mammary glands around puberty is widely held to be estrogen (E)-dependent. Here we report that several physiological changes associated… (More)
DOI: 10.1073/pnas.1210527109

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10 Figures and Tables