Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

@article{Maeda2002DietinducedIR,
  title={Diet-induced insulin resistance in mice lacking adiponectin/ACRP30},
  author={N. Maeda and I. Shimomura and K. Kishida and H. Nishizawa and M. Matsuda and H. Nagaretani and N. Furuyama and H. Kondo and Masahiko Takahashi and Y. Arita and R. Komuro and N. Ouchi and S. Kihara and Y. Tochino and K. Okutomi and M. Horie and S. Takeda and T. Aoyama and T. Funahashi and Y. Matsuzawa},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={731-737}
}
Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone, by disrupting the gene that encodes it in mice. Adiponectin/ACRP30-knockout (KO) mice showed delayed clearance of free fatty acid in plasma, low levels of fatty-acid transport protein 1 (FATP-1) mRNA in muscle, high levels of tumor necrosis factor-α (TNF-α) mRNA in adipose tissue and high plasma TNF-α concentrations. The KO mice exhibited severe diet-induced insulin resistance with reduced insulin… Expand
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