Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female.

@article{Waterland2007DietinducedHA,
  title={Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female.},
  author={Robert A. Waterland and Michael Travisano and Kajal G Tahiliani},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 12},
  pages={3380-5}
}
The effects of nonmutagenic environmental exposures can sometimes be transmitted for several generations, suggesting transgenerational inheritance of induced epigenetic variation. Methyl donor supplementation of female mice during pregnancy induces CpG hypermethylation at the agouti viable yellow (A(vy)) allele in A(vy)/a offspring. Epigenetic inheritance occurs at A(vy); when passed through the female germ line, A(vy) epigenotype is not completely "reset." We therefore tested whether diet… CONTINUE READING

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