Diet-induced hypercholesterolemia impaired testicular steroidogenesis in mice through the renin-angiotensin system.

@article{MartnezMartos2011DietinducedHI,
  title={Diet-induced hypercholesterolemia impaired testicular steroidogenesis in mice through the renin-angiotensin system.},
  author={Jos{\'e} Manuel Mart{\'i}nez-Martos and Marce Arrazola and Mar{\'i}a Dolores Mayas and Mar{\'i}a del Pilar Carrera-Gonz{\'a}lez and Mar{\'i}a Jes{\'u}s Garc{\'i}a and Mar{\'i}a Jes{\'u}s Ram{\'i}rez-Exp{\'o}sito},
  journal={General and comparative endocrinology},
  year={2011},
  volume={173 1},
  pages={15-9}
}
Hypercholesterolemia and low testosterone concentrations in men are associated with a high risk factor for atherosclerosis. It is known that cholesterol serves as the major precursor for the synthesis of the sex hormones. The bioactive peptides of the renin-angiotensin-system localized in the gonads play a key role in the relation between cholesterol and testosterone by modulating steroidogenesis and inhibiting testosterone production. In the present work, we evaluated the effects of diet… CONTINUE READING

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