Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress.

@article{Stranahan2011DietinducedEI,
  title={Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress.},
  author={Alexis M Stranahan and Roy G. Cutler and Catherine Button and Richard S. Telljohann and Mark P. Mattson},
  journal={Journal of neurochemistry},
  year={2011},
  volume={118 4},
  pages={611-5}
}
The structure and function of the hippocampus, a brain region critical for learning and memory, is impaired by obesity and hyperlipidemia. Peripheral cholesterol and sphingolipids increase progressively with aging and are associated with a range of age-related diseases. However, the mechanisms linking peripheral cholesterol metabolism to hippocampal neuroplasticity remain poorly understood. To determine whether diets that elevate serum cholesterol influence lipid metabolism in the hippocampus… CONTINUE READING

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