Diet-induced adipocyte number increase in adult rats: a new model of obesity.

@article{Faust1978DietinducedAN,
  title={Diet-induced adipocyte number increase in adult rats: a new model of obesity.},
  author={Irving M. Faust and P. R. Johnson and Judith S. Stern and Jules Hirsch},
  journal={The American journal of physiology},
  year={1978},
  volume={235 3},
  pages={
          E279-86
        }
}
Adult rats of various strains became obese when they were fed a highly palatable diet for several months. Analysis of their adipose tissue morphology revealed increases in both adipocyte size and number in most depots. Reintroduction of an ordinary chow diet to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. Adipocyte number remained at the elevated level achieved during the period of weight gain. Thus, transient dietary obesity in… CONTINUE READING
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