Diet and the aetiology of temporal advances in human and rodent sexual development

@article{Ashby2000DietAT,
  title={Diet and the aetiology of temporal advances in human and rodent sexual development},
  author={John Ashby and Helen Tinwell and Jenny Odum and Ian Kimber and Anthony Nigel Brooks and Ian Pate and C C Boyle},
  journal={Journal of Applied Toxicology},
  year={2000},
  volume={20}
}
2. Estrogenic activity can be assayed by measuring increases in uterine weight (“uterotrophic activity”) in immature or ovariectomised rodents. These models are used as they have low or no production of endogenous estrogens and are therefore, more sensitive to the administration of exogeneous estrogens. Advances in the age at which vaginal opening or first oestrus occurs in rodents is also used as an assay for exogeneous estrogens. 
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27 Citations
Background Citations
10
Methods Citations
3

27 Citations

Citation Type

Citation Type

Cumulative Dietary Energy Intake Determines the Onset of Puberty in Female Rats
TLDR
The relationship between cumulative energy intake and sexual maturation in female rats is investigated and infant formula at different concentrations and synthetic diets, with a wide range of metabolizable energy (ME) values, were used to modulate energy intake.
Effect of rodent diets on the sexual development of the rat.
  • J. Odum, H. Tinwell, +6 authors J. Ashby
  • Biology
    Toxicological sciences : an official journal of the Society of Toxicology
  • 2001
TLDR
The present data indicate that choice of diet may influence the timing of sexual development in the rat, and that when evaluating the potential endocrine toxicity of chemicals, the components of rodent diets used should be known, and as far as is possible, controlled.
Immature uterotrophic assay of estrogenic compounds in rats given diets of different phytoestrogen content and the ovarian changes with ICI 182,780 or antide
TLDR
The present findings demonstrate that the sensitivity of the immature rat uterotrophic assay is not influenced by the relatively low level of phytoestrogen in diets and that the ovarian changes occurring with genistein and ethinylestradiol are different.
The influence of dietary isoflavone on the uterotrophic response in juvenile rats.
Effect of gonadotropin-releasing hormone antagonist on ovarian and uterine weights in immature female rats.
Dietary factors affecting uterine weights of immature CD-1 mice used in uterotrophic bioassays.
Detection of estrogenically active substances in diets for sows by an in vitro bioassay supported by HPLC analysis.
TLDR
Clinically relevant zearalenone concentrations displayed estrogenic effects in the bioassay that did not differ significantly from those caused by high isoflavone concentration because of the use of soy as protein source, but further estrogenically active substances might also be involved in cases of impaired fertility.
The effects of the phytoestrogen genistein on the postnatal development of the rat.
TLDR
Although genistein is estrogenic at 40 mg/kg/day, this dose does not have the same repercussions as DES in terms of the organizational effects on the SDN-POA, as illustrated by the effects described above.
Increasing the sensitivity of the rodent uterotrophic assay to estrogens, with particular reference to bisphenol A.
  • J. Ashby
  • Biology
    Environmental health perspectives
  • 2001
TLDR
It is concluded that the case has yet to be made for augmenting the gravimetric end point of the uterotrophic assay, and it will be necessary to conduct detailed dose-response studies where the no-observed-effect level (NOEL) for the proposed surrogate end points are compared with the NOEL for the gravitical end point.
Effects of lactational exposure to soy isoflavones on reproductive system in neonatal female rats.
TLDR
Lactational exposure to isoflavones could result in oestrogen-like actions on the reproductive system of neonate female rats, which mechanisms may be, at least, involved with modifications of hormone production and steroid receptor transcription in the Reproductive system.
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References

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TLDR
It is shown that exposing female mouse fetuses to an EEDC at a dose that is within the range typical of the environmental exposure of humans alters the postnatal growth rate and brings on early puberty in these mice.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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