Diet and prostate cancer: mechanisms of action and implications for chemoprevention

  title={Diet and prostate cancer: mechanisms of action and implications for chemoprevention},
  author={Vasundara Venkateswaran and Laurence H. Klotz},
  journal={Nature Reviews Urology},
As one of the most prevalent cancers, prostate cancer has enormous public health significance and prevention strategies would attenuate its economic, emotional, physical and social impact. Until recently, however, we have had only modest information about risk factors for this disease, apart from the well-established characteristics of age, family history and place of birth. The large worldwide variation in the incidence of prostate cancer and the increased risk in migrants who move from low… 

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Until further clinical trial data are available on specific supplements and prostate cancer prevention, it would be prudent to emphasize a diet consisting of a wide variety of plant-based foods and fish; this is similar to what is recommended for the primary prevention of heart disease.

Dietary Agents in the Chemoprevention of Prostate Cancer

This article summarizes epidemiological, clinical, and mechanistic studies and the significance of plant-derived dietary agents such as flavonoids, indoles, isothiocyanates, phenolics, monoterpenes, and complementary and alternative agents in the management of prostate cancer with recommendations for future studies to advance this area of research.

Dietary fat and prostate cancer: current status.

It is concluded that dietary fat may indeed be related to prostate cancer risk, although the specific fat components that are responsible are not yet clear.

Selenium and prostate cancer: biological pathways and biochemical nuances

The in vitro and in vivo efficacy of selenium, mechanism of anti-carcinogenic action and synergy with micronutrients including its possible function in chemoprevention are discussed.

Prostate cancer prevention

The evidence and scientific data of a variety of prevention strategies including dietary fat reduction and supplementation with vitamins D and E, and selenium, and Dietary intake of soy, green tea, and tomato‐rich products (lycopene) are reviewed.

Risk Factors for Prostate Cancer

In the control of prostate cancer, the identification of risk factors and the promotion of active preventive medicine can provide enormous benefits to the super-aging society of the authors' future.

Clinical trials in cancer prevention: current results and perspectives for the future.

Nutritional science can play an important role in this effort through the use of new and emerging technologies to better understand the influence of bioactive food components on the genes, proteins, and cellular processes that are associated with cancer risk.

A prospective study of dietary fat and risk of prostate cancer.

The hypothesis that animal fat, especially fat from red meat, is associated with an elevated risk of advanced prostate cancer is supported and recommendations to lower intake of meat are supported to reduce the risk of prostate cancer.

Dietary intervention in the management of prostate cancer

The strongest evidence regarding diet and prostate cancer relates to energy balance, and Urologists aspiring to best clinical practice should encourage their patients to achieve a healthful body weight through regular exercise and a healthfully plant-based diet rich in fruits, vegetables, and whole grains.