Diet Modulates Th-1 and Th-2 Cytokine Production in the Peripheral Blood of Lupus-Prone Mice

@article{Jolly1999DietMT,
  title={Diet Modulates Th-1 and Th-2 Cytokine Production in the Peripheral Blood of Lupus-Prone Mice},
  author={Christopher A. Jolly and Gabriel Henrique Barroso Viana Fernandes},
  journal={Journal of Clinical Immunology},
  year={1999},
  volume={19},
  pages={172-178}
}
Calorie restriction or fish oil extends life span. To investigate the potential mechanism(s) involved, young (4-month) and old (9-month) NZB × NZW(F1) mice were fed 5% (w/w) corn oil (CA) or fish oil (FA) ad libitum or 40% restricted (CR and FR, respectively). Peripheral blood T-lymphocytes were analyzed for Th-1 (IL-2, IFN-γrpar; and Th-2 (IL-5, IL-10) production. CR and FA partially blunted while FR completely abolished the decline in aged CD4+ T lymphocytes. In contrast, both CR and FR… CONTINUE READING