Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss.

  title={Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss.},
  author={Munira Muluke and Tziporah Gold and Kathryn Kiefhaber and A Al-Sahli and Romanita S. Celenti and Hong Jiang and Serge Cremers and Thomas E Van Dyke and Ulrike Schulze-Sp{\"a}te},
  journal={Journal of dental research},
  volume={95 2},
Obesity is associated with abnormal lipid metabolism and impaired bone homeostasis. The aim of our study was to investigate the impact of specific elevated fatty acid (FA) levels on alveolar bone loss in a Porphyromonas gingivalis-induced model of periodontal disease and to analyze underlying cellular mechanisms in bone-resorbing osteoclasts and bone-forming osteoblasts in mice. Four-week-old male C57BL/6 mice were randomly divided in groups and subjected to a palmitic acid (PA)- or oleic acid… CONTINUE READING
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