Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

@inproceedings{Shirakawa2011DietInducedAT,
  title={Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice},
  author={Jun Shirakawa and Hideki Fujii and Kei Ohnuma and Koichiro Sato and Yuzuru Ito and Mitsuyo Kaji and Eri Sakamoto and Megumi Koganei and Hajime Sasaki and Yoji Nagashima and Kikuko Amo and Kazutaka Aoki and Chikao Morimoto and Eiji Takeda and Yasuo Terauchi},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE Diet composition alters the metabolic states of adipocytes and hepatocytes in diabetes. The effects of dipeptidyl peptidase-4 (DPP-4) inhibition on adipose tissue inflammation and fatty liver have been obscure. We investigated the extrapancreatic effects of DPP-4 inhibition on visceral fat and the liver. RESEARCH DESIGN AND METHODS We investigated diet-induced metabolic changes in β-cell-specific glucokinase haploinsufficient (Gck(+/-)) diabetic mice. We challenged animals with a… CONTINUE READING
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