Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes

@article{Slattery2010DietPA,
  title={Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes},
  author={Martha L. Slattery and Karen Curtin and Roger K Wolff and Jennifer S. Herrick and Bette Jane Caan and Wade S. Samowitz},
  journal={Cancer Causes & Control},
  year={2010},
  volume={21},
  pages={1237-1245}
}
Diet and lifestyle factors have been inconsistently associated with rectal tumors. It is possible that evaluation of specific tumor markers with these factors may help clarify these associations. In this study, we examine energy contributing nutrients, dietary fiber, BMI (kg/m2), and long-term physical activity with TP53 mutations, KRAS2 mutations, and CpG Island Methylator Phenotype (CIMP) in 750 population-based cases of rectal cancer compared to healthy controls. We observed that high levels… CONTINUE READING