Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism.

@article{Amara2007DieselEP,
  title={Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism.},
  author={Nadia Amara and Rafik Bachoual and Mathieu Desmard and S. Anita Johannah Golda and C{\'e}cile Guichard and Sophie Lanone and Michel Aubier and Eric Ogier-Denis and Jorge Boczkowski},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 1},
  pages={L170-81}
}
Chronic exposure to particulate air pollution is associated with lung function impairment. To determine the molecular mechanism(s) of this phenomenon, we investigated, in an alveolar human epithelial cell line (A549), whether diesel exhaust particles (DEPs), a main component of particulate air pollution, modulates the expression and activity of the matrix metalloprotease (MMP)-1, a collagenase involved in alveolar wall degradation. Interaction of DEPs with cigarette smoke, which also produces… CONTINUE READING

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