Diesel exhaust particles increase IL-1β-induced human β-defensin expression via NF-κB-mediated pathway in human lung epithelial cells

@article{Nam2005DieselEP,
  title={Diesel exhaust particles increase IL-1β-induced human β-defensin expression via NF-κB-mediated pathway in human lung epithelial cells},
  author={Hae Yun Nam and Eun-Kyung Ahn and Hyung Jung Kim and Young Wook Lim and Chun Beoun Lee and Kyo Lee and Val Vallyathan},
  journal={Particle and Fibre Toxicology},
  year={2005},
  volume={3},
  pages={9 - 9}
}
Human β-defensin (hBD)-2, antimicrobial peptide primarily induced in epithelial cells, is a key factor in the innate immune response of the respiratory tract. Several studies showed increased defensin levels in both inflammatory lung diseases, such as cystic fibrosis, diffuse panbronchiolitis, idiopathic pulmonary fibrosis and acute respiratory distress syndrome, and infectious diseases. Recently, epidemiologic studies have demonstrated acute and serious adverse effects of particulate air… CONTINUE READING
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