Diesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity

@inproceedings{Levesque2011DieselEA,
  title={Diesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity},
  author={Shannon Levesque and Thomas Taetzsch and Melinda E. Lull and Urmila P Kodavanti and Krisztian Stadler and Alison F. Wagner and Jo Johnson and Laura Duke and Prasada Rao S. Kodavanti and Michael Joseph Surace and Michelle L. Block},
  booktitle={Environmental health perspectives},
  year={2011}
}
BACKGROUND Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms underlying DE-induced microglia activation, neuroinflammation, and dopaminergic (DA) neurotoxicity. METHODS Rats were exposed to DE (2.0, 0.5, and 0 mg/m3) by inhalation over 4 weeks or as a single intratracheal administration of DE particles (DEP… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2004
VIEW 5 EXCERPTS

Determination of cellular H2O2 production.

  • Science's STKE : signal transduction knowledge environment
  • 2003
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Comparative evaluation of the effects of short - term inhalation exposure to diesel engine exhaust on rat lung and brain

D vanBerlo, C Albrecht, +3 authors IM Kooter
  • Arch Toxicol
  • 2010