Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.

@article{Wilde2017DiencephalicSI,
  title={Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.},
  author={Jonathan J Wilde and Julie A. Siegenthaler and Sharon Y R Dent and Lee Niswander},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2017},
  volume={37 10},
  pages={2565-2579}
}
Diencephalic defects underlie an array of neurological diseases. Previous studies have suggested that retinoic acid (RA) signaling is involved in diencephalic development at late stages of embryonic development, but its roles and mechanisms of action during early neural development are still unclear. Here we demonstrate that mice lacking enzymatic activity of the acetyltransferase GCN5 ((Gcn5hat/hat )), which were previously characterized with respect to their exencephalic phenotype, exhibit… CONTINUE READING
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