Dielectrophoretic detection and quantification of hybridized DNA molecules on nano-genetic particles.

Abstract

DNA-DNA hybridization reactions on 100 nm oligonucleotide-functionalized silica nanoparticles are found to sensitively affect the amplitude and direction of the dielectrophoretic mobility of the particles at nanomolar target ssDNA concentrations. Such sensitivity permits visual detection of the hybridization event without fluorescent labeling and confocal… (More)
DOI: 10.1002/elps.200800528

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