Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway

@inproceedings{Zhang2011DieckolFE,
  title={Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway},
  author={Chen Zhang and Yong Li and Zhong-Ji Qian and Sang-Hoon Lee and Yong-Xin Li and Se-kwon Kim},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
  year={2011}
}
The matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. In the present study, dieckol was obtained with high yield from marine brown alga Ecklonia cava (EC), and its effect was assessed on the expression of MMP-2 and -9 and morphological changes in human fibrosarcoma cell line (HT1080). Dieckol inhibited the expression of MMP-2 and -9 in a dose… CONTINUE READING