Die frühzeitige Elimination der Amanita Toxine in der Therapie der Knollenblätterpilzvergiftung

  title={Die fr{\"u}hzeitige Elimination der Amanita Toxine in der Therapie der Knollenbl{\"a}tterpilzvergiftung},
  author={M. Langer and S. Vesconi and G. Iapichino and D. Costantino and D. Radrizzani},
  journal={Klinische Wochenschrift},
SummaryIn a 3 year period (1975–77) 50 patients have been admitted to the I.C.U. of Polyclinic Hospital of Milan for poisoning from mushrooms of Amanita genus. In 47 cases the diagnosis was confirmed “a posteriori” by serum or urinary detection of amatoxins and/or by clinical evidence of typical liver injury.Besides the symptomatologic support, the therapeutic treatment included combined removal procedures, such as peritoneal dialysis, plasmapheresis, forced diuresis.The detection by… 
4 Citations
Hepatotoxic mushroom poisoning: diagnosis and management
The physio-pathological features and the clinical picture of amatoxin poisonings are described, as the basis for diagnosis and therapeutic decisions, and the treatment schedule proposed is analyzed.
Three Controversial Issues in Extracorporeal Toxin Removal
This work presents three issues dealing with extracorporeal removal of toxins for which there is no definitive answer but which may arise in clinical practice and concludes that rapidity in toxin removal is beneficial.
Toxicokinetics of labeled amatoxins in the dog
Two suggestions may be derived for the therapy of Amanita intoxication in man, detection in the urine of amatoxins 2 or 3 days after mushroom ingestion points to an ongoing amatoxin absorption or reabsorption from the intestine, and should lead to therapy with adsorbents and, in the absence of diarrhea, with laxatives.
The Role of Therapeutic Plasma Exchange in Poisonings and Intoxications
Therapeutic plasma exchange has several unique characteristics that allow it to be a potentially effective therapy in rapidly achieving this goal and recent data suggest that TPE may also be effective in the therapy of patients receiving biologic treatments who develop life‐threatening complications due to therapy.


Treatment of experimental poisoning produced by extracts of Amanita phalloides.
It is suggested that the fatalities after single lethal doses of the mushroom extract were caused predominantly by phallotoxins, whereas with fractionated administration of the extract, the fatalities may be due mainly to amatoxic effects.
[Elimination of toxic peptides from amanita phalloides by charcoal perfusion in vitro (author's transl)].
Charcoal perfusion in vitro resulted in virtually complete detoxication of an extract from 170 g of Amanita phalloides in aqueous or plasma protein solution, eliminating toadstool toxin and amanitin.
Production of antibodies to amanitins as the basis for their radioimmunoassay
A radioimmunoassay was developed which allows detection of as little as 0.5 ng of amanitins in 1 ml of serum and the clearance of α-amanitin from the blood of poisoned mice was measured.
Neue Gesichtspunkte zur Therapie yon Vergiftungen durch den griinen Knollenbl~itterpilz (Amanita phalloides) Schweiz
  • Med. Wochenschr. 102, 901-909
  • 1972
Amanita-phalloides-related nephropathy.
L ' intoxication phaltoidi ' enne
  • 1977
Applicazione clinica della plasmaferesi . Problemi tecnici
  • Anestesia e Rianimazione
  • 1976
Elimination yon Knollenbl ~ itterpilzgift ( Amanitine ) durch KohlePerfusion in vitro
  • Dtsch , Med . Wochenschr .
  • 1976